Alnylam Initiates P-III ILLUMINATE-B Study of Lumasiran for Primary Hyperoxaluria Type 1 (PH1) in Pediatric Patients
Shots:
- The P-III ILLUMINATE-B study will assess Lumasiran in 8 patients with primary hyperoxaluria type 1 (PH1) aged < 6yrs.- associated 1EPs as reduction of urinary oxalate in 6mos. & 2EPs as evaluating glomerular filtration rate (GFR)- safety- tolerability- with its expected initial results in mid-2020
- The company also reports the result of P-II OLE study result assessing lumasiran (1.0 & 3.0 mg/kg monthly- and 3.0 mg/kg quarterly) in patients and resulted in 72% reduction in urinary oxalate excretion- mean reduction relative to baseline 69%; 77% reduction in urinary 24-hour oxalate : creatinine ratio
- Lumasiran (formerly ALN-GO1- SC) is an RNAi therapeutics targeting glycolate oxidase (GO) and has received FDA’s BT & ODD- EU’s ODD & EMA’s PRIME Designation
Ref: Alnylam | Image: FDA Headlines
Click here to read the full press release
This content piece was prepared by our former Senior Editor. She had expertise in life science research and was an avid reader. For any query reach out to us at connect@pharmashots.com